Launched in the year 2151, the NX-class starship Enterprise (the first of United Earth's advanced warp five vessels) was at first on temporary assignment. Though years of preparation still lay ahead, the ship was unexpectedly put into service when a Klingon national crash-landed on Earth, putting the entire planet at stake should he not make it back to his people. Under the command of United Earth Starfleet Captain Jonathan Archer, son of the famed scientist Henry Archer, the crew of Enterprise succeeded in their mission, but found themselves surrounded by deeper mysteries. Warranting the extension of their assignment into a full-blown mission of deep space exploration, the crew of Enterprise set off into the unknown, taking with them a Vulcan science officer named T'Pol and a Denobulan doctor named Phlox.

Enterprise's first years were rocky; while the ship made contact with such species as the Suliban and the previously mentioned Klingons, such contact was not peaceful. In its first two years alone, the ship's crew found themselves in armed conflict with a range of species from the Tholians to the Coridanite to the Borg... and things only got worse. By its third year in space, an alien species known as the Xindi brutally attacked Earth, killing millions. The NX-01 was dispatched to a remote and previously uncharted area of space known as the Delphic Expanse in order to prevent the Xindi from completing their ultimate goal of destroying Humanity. While the mission was successful, after nearly a year in the Expanse, the ship suffered severe damage and many losses. Upon returning home, Enterprise served a more diplomatic role in the service of United Earth, easing relations between the Vulcans, the Andorians, and the Tellarites, and paving the way toward a Coalition of Planets, an alliance that eventually lead to the founding of the United Federation of Planets. Though still often tumultuous, Enterprise continued its mission of exploration as well, bringing Humans in contact with even more new worlds and new civilizations.

Jonathan Archer, played by Scott Bakula, is Captain of Earth's first Warp 5 starship, Enterprise. His father, Henry, designed its engine, giving Archer a personal connection to his ship. He was envisaged as being a cross between Chuck Yeager and Han Solo by executive producer Rick Berman, while Brannon Braga said that he was more "laidback and relatable". The character was initially openly prejudiced against the Vulcans, but this softens over time. T'Pol, played by Jolene Blalock, is Science Officer of Enterprise, originally attached to Enterprise by the Vulcan High Command to keep the humans out of trouble. She becomes loyal to Archer, leaving her position in the High Command to accompany him to find the Xindi, and later joins Starfleet. In later seasons, she forms a romantic relationship with Tucker.

Charles "Trip" Tucker III, played by Connor Trinneer, is Chief Engineer of Enterprise and a longtime friend of Captain Archer. He starts the series as a conservatively modest personality, but becomes more seasoned and outspoken as the series runs. In later seasons, he forms a romantic relationship with T'Pol. Malcolm Reed, played by Dominic Keating, is Tactical Officer of Enterprise, also in charge of ship security. Reed comes from a long line of Royal Navy men, but joined Starfleet because of his fear of drowning. An extremely taciturn man, his own family, when asked, could not name his favorite food (pineapple). Hoshi Sato, played by Linda Park, is Communications Officer of Enterprise and linguistic genius. Capable of learning alien languages extremely quickly, Hoshi serves as the interpreter between the crew of Enterprise and new alien species, even after the universal translator is on-line. She suffered anxiety about her place on board originally, but exposure to frequent danger helped her realize her value to the ship. Her confidence increases to the point Archer leaves her in command of Enterprise and she faces down the President of United Earth in "These Are The Voyages ..."

Travis Mayweather, played by Anthony Montgomery, is the Helmsman of Enterprise. A "space boomer," Travis is unique on Enterprise, having been born in space. Son of a freighter captain, Travis knows many of the alien species as well as locations that Earth traders frequent. As Enterprise moves farther and farther from Earth, his value in this area lessens, but his skill at the helm is constantly appreciated, making him the pilot of choice for many missions. Dr Phlox, played by John Billingsley, is Ship's Physician (not Chief Medical Officer, as he is not in Starfleet) of Enterprise. A Denobulan member of the Inter-Species Medical Exchange, he is brought aboard Enterprise to care for the Klingon passenger during the ship's first mission. He then volunteers to stay on, delighting in the experience of humanity taking its first steps onto the galactic stage. An exceedingly cheerful alien, Dr. Phlox uses many animals and naturalistic cures in his practice, in addition to the usual technological methods.

Scott Bakula ..... Captain Jonathan Archer
Connor Trinneer ..... Commander Charles Tucker III
Jolene Blalock ..... Commander T'Pol
Dominic Keating ..... Lieutenant Malcolm Reed
Anthony Montgomery ..... Ensign Travis Mayweather
Linda Park ..... Lieutenant Commander Hoshi Sato
John Billingsley ..... Dr Phlox

Abby Brammell ..... Persis
Ada Marentes ..... Captain Hernandez
Brent Spiner ..... Doctor Arik Soong
Bruce Davison ..... Menos
Christopher Darga ..... Captain Vorok
Clancy Brown ..... Zobral
Fionnula Flanagan ..... Ambassador V'Lar
Golden Brooks ..... Alicia Travers
Gary Graham ..... Ambassador Soval
Joel West ..... Raakin
James Beaver Jr ..... Rear Admiral Daniel Leonard
Jim Fitzpatrick ..... Commander Williams
Jeffrey Combs ..... Commander Thy'Lek Shran
James Cromwell ..... Zefram Cochrane
Jeffrey Ricketts ..... Imperial Guard Keval
Jonathan Frakes ..... William T Riker
John Fleck ..... Silik
Keith Carradine ..... Captain AG Robinson
Kellie Waymire ..... Crewman Cutler
Kara Zediker ..... T'Pau
Marina Sirtis ..... Deanna Troi
Mark Newman ..... Malik
Mark Mosos ..... Dr Henry Archer
Matt Winston ..... Agent Daniels
Peter Weller ..... John Paxton
Rick Worthy ..... Xindi Council Jannar
Robert Dean Stockwell ..... Colonel Grat
Steven Culp ..... Major Hayes
Scott MacDonald ..... Xindi Council Dolim
Thomas Kopache ..... Vulcal Diplomat
Tommy Lister Jr ..... Courier Klaang
Thomas Oglesby ..... Xindi Council Degra
Tucker Smallwood ..... Xindi Councilor
Rene Auberjonois ..... Ezral
Vaughn Armstrong Jr ..... Vice Admiral Maxwell Forrest
William Utay ..... Captain Vanik

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