The series begins in 2399, 20 years after Jean-Luc Picard's last appearance in Star Trek: Nemesis and finds the character still deeply affected by the death of Data in that film as well as the destruction of the planet Romulus in the film Star Trek (2009). Retired from Starfleet and living on his family's vineyard, Picard is drawn into a new adventure when he is visited by a synthetic "daughter" of Data, one of several new synthetic beings or "synths". Picard fights for their right to exist and gives his life to save them. After Picard's consciousness is transferred into a synthetic body, the second season moves forward to 2401. Picard and his companions are living new lives when his old adversary Q traps them in an alternate reality. They must travel back in time to the 21st century to save the future of the galaxy. In the third season, Picard learns that he has a son who is being hunted by mysterious enemies. He reunites with the former crew of the USS Enterprise to protect his son and face a new invasion by the Borg.
Patrick Stewart as Jean-Luc Picard: A retired Starfleet admiral who previously commanded the USS Enterprise. Picard retired from Starfleet in protest when the United Federation of Planets chose not to aid the Romulans when their planet was destroyed. He is diagnosed with a terminal illness in the first season, as the writers wanted to discuss relatable issues that people face at the end of their lives, and he dies at the end of the season. Picard's consciousness is transferred to a synthetic body, which led to widespread discussion by fans and critics regarding whether the synthetic version was still the same person. Co-creators Michael Chabon and Akiva Goldsman both felt he was the same character, but other commentators disagreed. More than a week of debates on the Star Trek wiki encyclopaedia Memory Alpha regarding whether or not a new wiki page should be created for the synthetic version of Picard ended with the information being kept on the same page. Picard is appointed Chancellor of Starfleet Academy by the second season, which explores the character's trauma from his mother's death by suicide when he was a child. This was inspired by Stewart's own experience of childhood domestic violence. In the third season, Picard is reunited with the former command crew of the Enterprise.
Alison Pill as Agnes Jurati: A former Starfleet doctor and expert on synthetic life who joins Picard. During the second season, Agnes is assimilated into the Borg Collective and becomes the new Borg Queen. Isa Briones as Dahj and Soji Asha, Sutra, and Kore Soong: Dahj and Soji are twin androids with organic bodies that were created to be the daughters of Data. Sutra is an earlier android model, and Kore is the daughter of Dr. Adam Soong from 2024. This helps explain by whom Data was inspired for the appearance of Dahj and Soji. Harry Treadaway as Narek: A Romulan agent sent to seduce and spy on Soji Asha. Michelle Hurd as Rafaella "Raffi" Musiker: Picard's former Starfleet first officer who struggles with substance abuse.
Santiago Cabrera as Cristobal "Chris" Rios: A former Starfleet officer and the pilot of La Sirena. Cabrera also portrays the emergency holograms aboard La Sirena. During the second season, Rios falls in love with a 21st century woman and opts not to return to the future. Evan Evagora as Elnor: A Romulan refugee whom Picard abandoned as a boy and was raised by the Qowat Milat, a sect of all-female warrior nuns. Jeri Ryan as Seven of Nine: A former Borg drone and crew member aboard the USS Voyager who became a member of the Fenris Rangers vigilante group. Orla Brady as Laris and Tallinn: Laris is Picard's Romulan housekeeper who develops romantic feelings for him. Tallinn is a Supervisor like the Star Trek: The Original Series character Gary Seven. Ed Speleers as Jack Crusher: The son of Beverly Crusher and Jean-Luc Picard.
Patrick Stewart ..... Jean-Luc Picard
Santiago Cabrera ..... Cristobal Rios
Michelle Hurd ..... Rafaella Musiker
Evan Evagora ..... Elnor
Alison Pill ..... Dr Agnes Jurati
Harry Treadaway ..... Narek
Isa Briones ..... Dahj & Soji Asha
Jonathan Frakes ..... William T Riker
LeVar Burton ..... Geordi La Forge
Michael Dorn ..... Worf
Gates McFadden ..... Beverly Crusher
Marina Sirtis ..... Deanna Troi
Orla Brady ..... Laris & Tallinn
Jeri Ryan ..... Seven of Nine
Ed Speleers ..... Jack Crusher
Annie Wersching ..... Borg Queen
Brent Spiner ..... Data
Amanda Plummer ..... Capitaine Vadic
Adele Shepherd ..... Kemi
Ashlei Chestnut ..... Sidney La Forge
Daniel Davis ..... Professor James Moriarty
Elizabeth Dennehy ..... Admiral Elizabeth Shelby
Ito Aghayere ..... Guinan
Jamie McShane ..... Zhaban
Jonathan Del Arch ..... Hugh
John Ales ..... Bruce Maddox
John de Lancie ..... Q
Kirk Acevedo ..... Krinn
Mica Burton ..... Alandra La Forge
Michelle Forbes ..... Commander Ro Laren
Penelope Mitchell ..... Renee Picard
Peyton List ..... Narissa
Rebecca Wisocky ..... Ramdha
Sol Rodriguez ..... Dr Teresa Ramirez
Tamlyn Tomita ..... Commodore Oh
Todd Stashwick ..... Captain Liam Shaw
Tim Russ ..... Tuvok
Thomas Dekker ..... Titus Rikka
Wil Wheaton ..... Wesley Crusher
Whoopi Goldberg ..... Guinan
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